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Acrilane is the most carcinogenic ingredient in cigarettes

In severe cases, it can cause cell death in the leg which might have to be removed surgically (amputated)

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Notably, not it any of these reports is one such MR study with evidence of cause and effect for high intake of alcohol and hypertension and coronary artery disease (Graphs below, note these are log plots)

But the DOH said scare tactics seem to have worked well among the Filipino smoking population. The GATS survey reported that the percentage of smokers who thought of quitting smoking because of health warnings on cigarette packs increased significantly from 37.4% in 2009 to 44.6% in 2015